Growth Hormone
IGF1-LR3
IGF-1 LR3 is an 83-amino-acid recombinant analog of insulin-like growth factor-1 with an N-terminal extension and Arg3 substitution. It is used to study IGF-1 receptor signaling, proliferation, differentiation, and survival pathways in cell culture and animal models.
- Quantity
- 1MG
- Purity
- See COA
Standard $9.99 | Expedited $12.99 | Free standard over $200
Download Certificate of AnalysisResearch overview
Research Overview
IGF-1 LR3 was engineered to decrease binding to IGF-binding proteins while retaining high affinity for the IGF-1 receptor, thereby increasing bioactivity in vitro.[1] It is a widely used tool in models of muscle biology, cartilage formation, neuronal survival, and metabolic regulation to map downstream PI3K/Akt and MAPK cascades.[2,3] All applications are confined to controlled experimental contexts.
Molecular Structure & Receptor Pharmacology
The extended N-terminus and Arg3 substitution reduce sequestration by IGFBPs, effectively increasing free ligand available for receptor activation.[1] This makes IGF-1 LR3 suitable for serum-reduced media, mechanistic phospho-signaling assays, and ligand–receptor binding studies.
Primary Research Applications
In myotube, osteoblast, chondrocyte, and neuronal cultures, LR3 is employed to quantify receptor phosphorylation, protein synthesis, glucose uptake, and survival endpoints.[2,3] These data underpin fundamental understanding of IGF-1 pathway regulation.
Extended Models
In vivo and ex vivo models use LR3 to investigate tissue growth, neuroprotective signaling, and metabolic adaptations, while anti-doping laboratories utilize it as a reference standard for analytical method development. None of these uses imply approved therapeutic protocols.
