OSYRIS
Selank

Cognitive

Selank

$39.99

Selank is a synthetic heptapeptide with the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. Structurally derived from the endogenous tetrapeptide tuftsin, Selank is classified as an anxiolytic and neuroregulatory research peptide. It has been widely studied for its impact on monoamine neurotransmitters, immune modulation, and neurotrophic factors. Supplied as a lyophilized powder, Selank is intended strictly for in vitro and in vivo research applications.

Quantity
10MG
Purity
See COA

Standard $9.99 | Expedited $12.99 | Free standard over $200

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Research On This Compound

Selank — The Anxiolytic Peptide That Came From the Immune System

10 min read · 6 citations · Cognitive
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Semax vs Selank — Two Russian Nootropics, Two Different Brains

Semax vs Selank compared: neurotrophic vs anxiolytic mechanisms. BDNF upregulation vs GABA modulation. Same lab, different parent molecules.
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Understanding GABAergic Neurotransmission

A plain-language explainer on inhibitory neurotransmission, GABA-A receptor biology, and why Selank is mechanistically different from classic sedatives.
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Practical Guides
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Research overview

Selank: Research Applications and Mechanisms

PubChem CID : 9943130Selank was developed by modifying the structure of tuftsin, a naturally occurring immunomodulatory peptide. The result is a longer-acting, more stable compound that retains both neuroactive and immunotropic properties. Research surrounding Selank focuses on its regulation of cytokines, brain monoamines, and GABAergic activity.

1. Neurotransmitter System and Anxiolytic Pathways

A significant area of Selank research involves its influence on monoamine neurotransmitters, particularly serotonin, dopamine, and norepinephrine.
  • In rodent studies, Selank has been shown to increase serotonin and dopamine levels in the hippocampus and frontal cortex [1].
  • These changes have been linked to its interaction with GABA-A receptors, suggesting that Selank may enhance GABAergic transmission indirectly [2].
Electrophysiological studies have explored how Selank affects neuronal firing rates and synaptic plasticity, offering a model for researching anxiolytic mechanisms without sedative effects.

2. Immune Modulation and Cytokine Research

Selank’s structural relation to tuftsin has made it a target in immunological studies, particularly for its effects on cytokine production and T-helper cell activity.
  • In vitro experiments on human peripheral blood cells show that Selank modulates levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) [3].
  • Animal studies support its role in balancing Th1/Th2 responses, indicating potential in models studying immune homeostasis [4].
Such findings are relevant to research in neuroimmune communication, where peptides influence both inflammatory responses and neural function.

3. Cognitive Function and Neurotrophic Factor Studies

Selank has also been studied for its role in modulating brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in the central nervous system.
  • Repeated administration in rodent models resulted in increased BDNF expression in the hippocampus and prefrontal cortex [5].
  • These results have been used to examine Selank’s effect on learning, memory formation, and synaptic modulation.
These experiments often use RT-PCR and immunohistochemistry techniques to quantify mRNA and protein levels in brain tissue.

4. Stress Adaptation and HPA Axis Research

Selank is involved in studies of the hypothalamic-pituitary-adrenal (HPA) axis, particularly in response to acute and chronic stress.
  • It has demonstrated the ability to normalize corticosterone levels in stressed rodents and stabilize ACTH secretion during experimental challenges [6].
  • Research has indicated its ability to blunt stress-induced monoamine imbalances in multiple brain regions.
This makes Selank a relevant peptide for stress physiology studies, where neuroendocrine regulation is a central focus.

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