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Home/Shop/Cognitive & Neurological/DSIP
DSIP research peptide vial — OSYRIS Health
COGNITIVE

DSIP

$29.99

DSIP is a synthetic nonapeptide corresponding to an endogenous peptide first associated with sleep regulation. It is used in neurobiology to investigate sleep–wake modulation, stress responses, and neuroendocrine signaling.

QuantityStandard research vial
PuritySee COA
Free shipping on orders over $200
Download Certificate of Analysis
Research On This Compound

DSIP — Sleep peptide research

8 min read · 5 citations · Sleep architecture, neuropeptides, circadian

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About This Compound

Product Overview

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (nine amino acids) with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first isolated in 1977 from the cerebral venous blood of rabbits during induced slow-wave sleep by Swiss researchers Schoenenberger and Monnier. The name derives from its original discovery context — it was found during delta-wave (deep sleep) brain activity.

DSIP is unique among the OSYRIS Cognitive & Neurological compounds because its research profile centers on sleep architecture — the structure and quality of sleep stages — rather than wakefulness-oriented cognitive functions. Sleep quality is a fundamental variable in neurological research and is increasingly studied as a factor in cognitive function, neuroplasticity, and neurodegeneration.

The compound has a molecular weight of approximately 849 g/mol and is widely distributed in the brain, with concentrations found in the hypothalamus, limbic system, and pituitary gland.

DSIP delta sleep wave neural activity research visualization — OSYRIS Health
Research Applications

Mechanism and Experimental Context

DSIP's original discovery in the context of slow-wave sleep led to extensive research into its effects on sleep architecture. Studies in animal models demonstrated that DSIP administration altered the distribution of sleep stages, with some studies showing increased slow-wave (delta) sleep duration and improved sleep continuity. The effects appear to be modulatory rather than sedative — DSIP influences sleep structure without producing the forced sedation characteristic of hypnotic drugs.1

Research in human subjects (conducted primarily in the 1980s-90s) showed variable results, with some studies reporting improved sleep quality and normalized sleep patterns in subjects with disrupted sleep, while others found minimal effects. The variability may reflect differences in dosing protocols and assessment methods.2

DSIP has been shown to modulate several neuroendocrine pathways. Research has demonstrated effects on ACTH and cortisol release, with DSIP appearing to normalize stress-induced hormonal responses in animal models. Studies also showed interactions with the somatotropic axis (growth hormone) and the opioid system — DSIP has weak affinity for certain opioid receptor subtypes.3

The neuroendocrine research suggests that DSIP may function as a broad neuromodulator rather than a compound with a single specific receptor target — influencing multiple systems that converge on sleep-wake regulation.

A line of research has investigated DSIP's effects in stress models. Studies in rats demonstrated that DSIP administration modulated the behavioral and hormonal response to various stressors, with treated animals showing reduced stress-related behavior in forced swim and restraint stress paradigms. These findings have been interpreted as reflecting DSIP's role in adaptive stress regulation rather than direct anxiolysis.4

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Referenced Studies

Source Literature

[1]

Schoenenberger GA, Monnier M. "Characterization of a delta-electroencephalogram sleep-inducing peptide." Proceedings of the National Academy of Sciences, 1977. PubMed: PMID 266735

[2]

Schneider-Helmert D, Schoenenberger GA. "Effects of DSIP in man." Neuropsychobiology, 1983. PubMed: PMID 6580595

[3]

Sudakov KV, et al. "Delta-sleep-inducing peptide and neuronal activity." Neuroscience and Behavioral Physiology, 2004.

[4]

Khvatova EM, et al. "Delta-sleep-inducing peptide: stress-protective activity." Bulletin of Experimental Biology and Medicine, 2003.

Certificate of Analysis

Batch Documentation

Current published batch documentation is surfaced on-page whenever the provider exposes a public COA asset.

DSIP certificate of analysis

Frequently Asked Questions

Questions About DSIP

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in 1977 from the brains of sleeping rabbits. It is studied for its effects on sleep architecture, neuroendocrine modulation, and stress response.

DSIP is not a sedative. Research suggests it modulates sleep architecture — the structure and staging of sleep — rather than forcing sedation. In animal studies, it influenced the duration of slow-wave (delta) sleep without producing hypnotic effects.

Sleep quality is fundamental to cognitive function. DSIP's research profile — sleep architecture, neuroendocrine modulation, and stress response — is directly relevant to neurological research. It complements the wakefulness-focused compounds in the category (Semax, Selank).

DSIP is distributed throughout the brain, with notable concentrations in the hypothalamus, limbic system, and pituitary gland. It has also been detected in peripheral blood.

No. DSIP is a research peptide sold exclusively for laboratory research.

Store lyophilized DSIP at 2-8°C for short-term or -20°C for long-term. Protect from light.

Every batch is independently tested via HPLC and LC-MS. The COA is downloadable on this page.

DSIP is a nonapeptide: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, with a molecular weight of approximately 849 g/mol.

Every Batch Tested by an Independent Lab

We publish the Certificate of Analysis for every product. See our full testing process.

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All products sold by OSYRIS Health are intended for laboratory research purposes only and are not for human or veterinary use. The information provided on this page describes published scientific research and does not constitute medical advice, diagnosis guidance, or a recommendation for any specific use. Always ensure compliance with local regulations.