SLU-PP-32's primary application is studying the molecular mechanisms of exercise adaptation without the variable of physical activity. By activating ERRs pharmacologically, researchers can investigate which exercise benefits are ERR-dependent and which require additional inputs like mechanical stress or calcium signaling.1
METABOLIC
SLU-PP-32
$74.99
SLU-PP-32 is an experimental ligand within the ERR (estrogen-related receptor) agonist family. Strictly for exploratory research on nuclear receptor signaling, mitochondrial regulation, and oxidative metabolism.
ClassERR Agonist
TargetPan-ERR
UseResearch Tool
PuritySee COA
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Product Overview
SLU-PP-32 is a synthetic pan-ERR (Estrogen-Related Receptor) agonist — a research compound that activates all three ERR subtypes (ERRα, ERRβ, ERRγ). Despite their name, Estrogen-Related Receptors do not bind estrogen; they are "orphan" nuclear receptors that regulate genes involved in energy metabolism, mitochondrial biogenesis, and oxidative phosphorylation.
ERRs are considered master regulators of exercise-induced metabolic adaptation. When you exercise, ERR activity increases in skeletal muscle, driving the expression of genes that improve mitochondrial density, fatty acid oxidation, and aerobic capacity. SLU-PP-32 activates these same receptors pharmacologically, making it a research tool for studying exercise-mimetic biology.
SLU-PP-32 was developed at Saint Louis University (hence the "SLU" designation) and represents a relatively new class of metabolic research tools.
Research Applications
Mechanism and Experimental Context
ERR activation drives the transcription of genes encoding mitochondrial proteins, including components of the electron transport chain and fatty acid oxidation enzymes. SLU-PP-32 is used to study whether pharmacological ERR activation can increase mitochondrial density in cell culture and animal models.2
As a pan-ERR agonist, SLU-PP-32 activates gene expression programs that overlap with those induced by exercise, caloric restriction, and cold exposure — three interventions known to improve metabolic health. Researchers use it to dissect which metabolic improvements are ERR-mediated.3
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Referenced Studies
Source Literature
[1]
Patch RJ, et al. "Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents." Journal of Medicinal Chemistry, 2011. PubMed: PMID 21190325
[2]
Rangwala SM, et al. "Estrogen-Related Receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity." Journal of Biological Chemistry, 2010.
[3]
Giguere V. "Transcriptional control of energy homeostasis by the estrogen-related receptors." Endocrine Reviews, 2008. PubMed: PMID 18436707
Certificate of Analysis
Batch Documentation
Current published batch documentation is surfaced on-page whenever the provider exposes a public COA asset.
Frequently Asked Questions
Questions About SLU-PP-32
SLU-PP-32 is a pan-ERR (Estrogen-Related Receptor) agonist developed at Saint Louis University. It activates all three ERR subtypes, which are nuclear receptors that regulate energy metabolism and mitochondrial biogenesis.
Despite the name, ERRs don't bind estrogen. They're "orphan" nuclear receptors that regulate genes involved in energy metabolism, mitochondrial biogenesis, and oxidative capacity. They're activated naturally during exercise.
A compound that activates some of the same molecular pathways as physical exercise. SLU-PP-32 activates ERRs, which drive exercise-induced metabolic gene expression. It doesn't replace exercise but helps researchers study which exercise benefits are ERR-dependent.
Both are studied as exercise mimetics but through different mechanisms. MOTS-C activates AMPK. SLU-PP-32 activates ERRs. These are different nodes in the metabolic signaling network.
No. SLU-PP-32 is a small molecule nuclear receptor agonist, not a peptide. It is included in the OSYRIS catalog as a metabolic research tool.
Follow the storage instructions on the product label. Typically stored at -20°C, protected from light and moisture.
Independently tested via HPLC and LC-MS. COA downloadable on this page.
"Pan" means "all." SLU-PP-32 activates all three ERR subtypes (ERRα, ERRβ, ERRγ) rather than being selective for one.
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